ISSN 1866-8836
Клеточная терапия и трансплантация

Epidemiology of bacterial infections and antibiotic resistance in BMT clinic: single center experience

Vladimir N. Vavilov1, Olga B. Ponomarenko1, Marina O. Popova1, Svetlana S. Emelyanova2, Maria Yu. Averjanova1, Oleg V. Goloschapov1, Ludmila S. Zubarovskaya1, Boris V. Afanasyev1

1Memorial R.M. Gorbacheva Institute of Children Hematology and Transplantation, St. Petersburg Pavlov State Medical University,
St. Petersburg, Russia; 2Petersburg Nuclear Physics Institute, Russian Academy of Science, St. Petersburg, Russia

Correspondence
Vladimir Vavilov, Memorial R.M. Gorbacheva Institute of Children Hematology and Transplantation, St. Petersburg Pavlov State Medical University, St. Petersburg, Russia
E-mail: vladimir_vavilov@mail.ru 

doi 10.3205/ctt-2009-No5-abstract22

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Cellular Therapy and Transplantation (CTT)
Volume 2, Number 1(5)
Contents 

Summary

Background

High-dose chemotherapy, hematopoietic stem cell transplantation (HSCT) and “graft-versus-host” disease treatment are associated with greatly increasing the risk of the most frequent and most life–threatening infectious complications.

Aim

The aim of this single-center study was to evaluate the epidemiology and antibiotic resistance of bacterial infections in oncohematological and HSCT patients.

Patients and methods

Three hundred consecutive, positive cultures were sampled from 79 high-risk patients. Cultures were provided with BacT/Alert® and Vitek® technologies.

Results

The organisms that most commonly caused infectious complications were
S. epidermidis, E. faecalis, E. faecium, S. aureus, K. pneumoniae,
Enterobacter spp., Acinetobacter spp.,
and P. aeruginosa.

The agents that most commonly caused bacteremia were S. epidermidis,
K. pneumoniae, P. aeruginosa, E. coli,
and E. faecalis. Compared with causes of bacteremia in 2006–2007, the study of 2008–2009 shows the superior but decreasing role of Gram-positive cocci and increasing rates of bacteremia episodes caused by Gram-negative agents.

Analysis of antibiotic resistance shows high efficacy of vancomycin and linezolid, cefoperazone/sulbactam and piperacillin, and moderate efficacy of carbapenems, quinolones, and aminoglycosides. In contrast, increasing resistance to some third generation cephalosporins (only ceftriaxone and ceftazidime) was observed.

We observed increasing rates of multiresistant strains of K. pneumoniae,
P. aeruginosa
and Acinetobacter spp. At the same time there is no increasing rates of Gram-positive cocci: only 12.5% of S. aureus were resistant to oxacillin (ORSA). Low rates of vancomycin resistant enterococci (VRE) infections were observed.

Conclusions

Our study shows the emerging role of Gram-negative bacteria with increasing rates of multiresistant strains. Analysis of antibiotic sensitivity shows that the principles of antimicrobial agents use in patients with hematological and oncological diseases treated in BMT clinics should be changed.

Keywords

stem cell transplantation, acute leukemia, infectious complications, antibiotic resistance


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