ISSN 1866-8836
Клеточная терапия и трансплантация

Anemias in lymphomas: pathogenesis mechanisms

Anna S. Lyamkina, Tatiana I. Pospelova

The State Medical University, City Hematological Center, Novosibirsk, Russia

Correspondence
Anna S. Lyamkina, GOU of the highest professional education "Novosibirsk State Medical University of Federal Agency of Healthcare and Social Development", 630091, Novosibirsk, 52, Krasniy Prospect, Russia
Phone: +7 (383) 279-94-06, fax: +7 (383) 279-94-06, E-mail: post_gem@mail.ru
doi 10.3205/ctt-2009-No5-abstract16

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Cellular Therapy and Transplantation (CTT)
Volume 2, Number 1(5)
Contents 

Summary

Aims

To spot the value of blood serum cytokines (IL-1β, IL-6, TNF-α, IF-γ) in the development of an anemic syndrome in patients with lymphoproliferative diseases.

Methods

We inspected 88 patients with lymphoproliferative diseases: T and B–cellular non–Hodgkin’s lymphomas and multiple myeloma. The level of serum interleukins (IL-1β, IL-6, TNF-α, IF-γ) was identified.

Results

Patients with lymphoproliferative diseases and an anemia had average levels of IL-1β, TNF-α, IF-γ in their blood serum that were 3.4, 2.8, and 14.4 times higher respectively than in patients with lymphomas without an anemia (p<0.05). The return correlation between levels of IL-1β, TNF-α, IF-γ and the level of erythropoietin serum (r=–0.79) confirms the importance of
IL-1β, TNF-α, IF-γ in an anemia pathogenesis at hemoblastoses. For 8.3% of patients with lymphomas and an anemia,  myelodysplasia tags, recorded levels of IL-1β and TNF-α were twice as high as patients with normal erythron. This indicates a probable role of the researched cytokines in the development of secondary myelodysplasia in patients with lymphomas.

The return correlation between IL-6 and erythron of bone marrow was available in patients with multiple myeloma (r=–0.96). IL-6 raises a proliferation of myeloma cells, which, in turn, displace and depress a proliferation of remaining sprouts of myelopoiesis, including erythroid.

Conclusions

The cited data bears the importance of cytokines IL-1β, IL-6, TNF-α, and
IF-γ in a pathogenesis of an anemic syndrome for patients with lymphoproliferative diseases.

Keywords

cytokines, lymphoproliferative diseases, anemia, non-Hodgkin’s lymphoma, multiple myeloma


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