ISSN 1866-8836
Клеточная терапия и трансплантация

Comparative analysis of acute myeloid leukemia treatment results in the Sverdlovsk Regional Clinical Hospital №1

Alexander V. Vinogradov, Tatiana S. Konstantinova, Alexander F. Tomilov, Vladimir A. Shalaev, Elena V. Chepuryaeva, Julia V. Sveshnikova, Leonid N. Sharov, Natalia V. Vinogradova

Ural State Medical Academy, Sverdlovsk Regional Clinical Hospital N1, Ekaterinburg, Russia

Correspondence
Ural State Medical Academy, Sverdlovsk Regional Clinical Hospital N1, Ekaterinburg, Russia, Gurzufskaya Str., 11/1-4, 620086 Ekaterinburg, Russia, Phone: +7 (343) 2683648, Fax: +7 (343) 2120146
E-mail: vinogradov-av@spam is badyandex.ru

doi 10.3205/ctt-2009-No5-abstract32

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Cellular Therapy and Transplantation (CTT)
Volume 2, Number 1(5)
Contents 

Summary

Aim

To estimate the prognostic significance of cytogenetic abnormalities in acute myeloid leukemia (AML) patients—who were treated according to the following chemotherapy protocols: RHSC AML 01.99, 01.01, and >60 years old.

Methods

A total of 125 AML pts were treated with RHSC AML 01.99, 01.01 and >60 y.o. protocols from 1999 to 2008. The distribution of pts by protocol was as follows: AML 01.99 – 16, AML 01.01 – 84, and AML >60 y.o. – 25. The cytogenetic variants of AML according to the protocols are presented in Table 1.

Results

The results of the comparative analysis of treatment results are presented in Table 2.

The results of the comparative analysis of treatment according to cytogenetics are presented in Table 3.

The comparative analysis of overall survival (OS) and relapse-free survival (RFS) of AML pts according to cytogenetics is presented in Figures 1 and 2.

Thus, in AML pts treated by RHSC AML 01.99, 01.01, and >60 y.o. protocols, only inv(16) has a favorable prognostic significance. All other cytogenetic subtypes were associated with unfavorable prognosis.

Keywords

acute myeloid leukemia, treatment, cytogenetic abnormalities



Table 1.

Protocol t(8;21), % inv(16), % 46,xy/46,xx, % Others, %
AML 01.01 20.3 18.8 26.1 34.8
AML 01.99 - 38.5 30.8 30.8
AML > 60 y.o. - 27.8 22.2 50.0

Table 2.

Characteristics AML 01.01 AML 01.99 AML > 60 y.o.
Early death    
n 8 1 4
% 9.5 6.3 16.0
Resistance    
n 28 2 4
% 33.3 12.5 16.0
Complete remission    
n 48 13 17
% 57.1 81.3 68.0
Relapses    
n 18 5 5
% 34.6 38.5 29.4
Remission death    
n 7 2 1
% 13.5 15.4 5.9

Table 3.

Characteristics t(8;21) Inv(16) 46,xy/46,xx t(9;22), abn(11q), etc. Others
Early death - 8.7 23.1 13.0 -
Resistance 7.7 13.0 23.1 43.5 61.5
Complete remission 92.3 78.3 57.7 43.5 38.5
Relapses 50.0 11.1 66.7 40.0 40.0
Remission death 16.7 11.1 13.3 10.0 20.0

Figure 1. Actuarial probability of AML pts’ OS according to cytogenetics

2009-5-en-Vinogradov-et-al-Figure-1.JPG


Figure 2. Actuarial probability of AML pts’ RFS according to cytogenetics

2009-5-en-Vinogradov-et-al-Figure-2.JPG

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