ISSN 1866-8836
Клеточная терапия и трансплантация

PO-04. Impact of patients’ age on the treatment adherence in allo-HSCT recipients

Elmira I. Kolgaeva, Mikhail Y. Drokov, Dmitri E. Vybornykh, Larisa A. Kuzmina, Elena N. Parovichnikova

National Research Center for Hematology, Moscow, Russia

Contact: Dr. Elmira I. Kolgaeva, phone: +7 (495) 614-90-42, e-mail:

doi 10.18620/ctt-1866-8836-2022-11-3-1-132


According to a 2003 WHO report, age is a socio-economic factor that impact on patients’ ability to follow doctor’s recommendations.


To demonstrate the effect of age on adherence among patients undergoing allo-HSCT.

Materials and methods

We analyzed 81 patients who entered the National Medical Research Centre of Hematology at the Russian Ministry of Health for allo-HSCT. The patients were diagnosed with acute myeloid leukemia (n= 48), and 33 patients were treated for acute lymphoblastic leukemia. The average age of the patients was 45 years, ranging from 18 to 63 years old. Adherence to treatment and medical care was studied using a specialized questionnaire KOP-25. The answers to each question were evaluated as point scores, then being summarized, and quantitative indices were calculated. On the basis of obtained scores, the indices of adherence were calculated having been expressed as conditional percentages. Differential indexes concerned adherence to the lifestyle changes, drug therapy, and medical care. We used scatter diagrams and regression analysis (LOESS method).


The results of our study have shown similar reverse relationships between the patient’s age and adherence to the lifestyle (Cc) modification, drug therapy (Cd), and medical care (Cm). Moreover, we noted an age-dependent effect upon the integral index of adherence (С).


On the basis of the data obtained, we have concluded that the adherence for treatment shows a decrease for all tested indices with the patients’ age.


Allogeneic HSCT, recipients, adherence to lifestyle modification, adherence to drug therapy, adherence to medical care.

Volume 11, Number 3

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doi 10.18620/ctt-1866-8836-2022-11-3-1-132

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