ISSN 1866-8836
Клеточная терапия и трансплантация

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Experimental studies

Morphology of hybrid doxorubicin delivery systems (dextran sulfate-coated CaCO3 vaterites) in human blood plasma

Natalia N. Sudareva1,2, Olga М. Suvorova1, Natalia N. Saprykina1, Vladimir V. Tomson2, Dmitry N. Suslov3, Oleg V. Galibin2, Aleksandr D. Vilesov1,2

Experimental studies

Morphology of hybrid doxorubicin delivery systems (dextran sulfate-coated CaCO3 vaterites) in human blood plasma

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Natalia N. Sudareva1,2, Olga М. Suvorova1, Natalia N. Saprykina1, Vladimir V. Tomson2, Dmitry N. Suslov3, Oleg V. Galibin2, Aleksandr D. Vilesov1,2

1 Institute of Macromolecular Compounds RAS, St. Petersburg, Russia
2 Pavlov University, St. Petersburg, Russia
3 A. M. Granov Russian Research Center of Radiology and Surgical Technologies, St. Petersburg, Russia


Correspondence
Dr. Natalya N. Sudareva, Institute of Macromolecular Compounds, Bolshoy Ave 31, Vassilievsky Island, 199004, St. Petersburg, Russia
E-mail: nnsas@mail.ru

In a number of cases, efficiency of cancer therapy may be enhanced by local administration of chemotherapeutic drugs into the tumor area. After regional injection, a drug, or appropriate delivery system is exposed to the interstitial fluid, which differs from blood plasma, mainly, in lesser protein amounts. In the present work, we studied the influence of human blood plasma upon structure and properties of hybrid drug delivery systems based on calcium carbonate (СаСО3) vaterites coated with polyelectrolyte dextran sulfate (DexS). These delivery systems included anti-cancer drug doxorubicin (DOX).

It has been shown that DexS-modified vaterites provided the prolonged release of DOX to blood plasma. SEM microphotographs revealed structural changes in hybrid delivery systems occurring in plasma and correlating with the DOX release profiles.

Keywords

Doxorubicin, drug delivery system, СаСО3, dextran sulfate, blood plasma.