ISSN 1866-8836
Клеточная терапия и трансплантация

Volume 5, Number 1
03/01/2016
Volume 5, Number 1
Editor-in-Chief
Afanasyev B. V. (St. Petersburg, Russia)
Co-Editors-in-Chief
Wagemaker G. (Rotterdam, Netherlands)
Zander A.R. (Hamburg, Germany)
Deputy Editor
Fehse B. (Hamburg, Germany)
Managing Editor
Chukhlovin A. B. (St. Petersburg, Russia)
Editorial Board
Aleynikova O. V. (Minsk, Belarus)
Baum C. (Hannover, Germany)
Bilko N. M. (Kyiv, Ukraine)
Borset M. (Trondheim, Norway)
Büchner Th. (Münster, Germany)
Chechetkin A. V. (St. Petersburg, Russia)
Fibbe W. (Leiden, Netherlands)
Galibin O. V. (St. Petersburg, Russia)
Gritsaev S. V. (St. Petersburg, Russia)
Hölzer D. (Frankfurt a.M., Germany)
Klimko N. N. (St. Petersburg, Russia)
Kolb H.-J. (München, Germany)
Kröger N. (Hamburg, Germany)
Kulagin A. D. (St. Petersburg, Russia)
Lange C. (Hamburg, Germany)
Mamaev N. N. (St. Petersburg, Russia)
Mikhailova N. B. (St. Petersburg, Russia)
Moiseev I. S. (St. Petersburg, Russia)
Nagler A. (Tel-Aviv, Israel)
Nemkov A. S. (St. Petersburg, Russia)
Paramonov I. V. (Kirov, Russia)
Roumiantsev A. G. (Moscow, Russia)
Savchenko V. G. (Moscow, Russia)
Smirnov A. V. (St. Petersburg, Russia)
Uss A. L. (Minsk, Belarus)
Zubarovskaya L. S., (St.Petersburg, Russia)
In this Issue

Despite a wide scope of the CTT editorial policy, hematopoietic stem cell transplantation (HSCT) and related topics remain central to our readership, due to advanced research in this field. Chronic myeloid leukemia (CML) is the example of such a fast evolution in diagnostics and therapy over last decades. A review article by Rüdiger Hehlmann and Susanne Saußele illustrates differential approaches with tyrosine kinase inhibitors (TKIs) and HSCT as first- and second-line strategies of CML treatment, with regard to individual risk factors, thus providing optimal outcomes in terms of overall survival and achieving molecular remissions.

Clinical efficiency of leukemia treatment is now measured by dropping levels of specific oncogenic markers after the therapy performed. Professor Robert P. Gale presents an elegant article dedicated to accuracy of molecular tests, aiming efficiency evaluation and improved quality of the leukemia relapse prediction. The article will be of value to both clinicians and laboratory hematologists.

The usage of autologous marrow stem cells transplantation for treatment of myocardial disorders still remains under discussion. In spite of positive clinical effects of such treatment in certain cases, there are some controversies concerning engraftment and long-term in situ effects of the stem cells injected. In this respect, the article from a German team lead by Professor Steinhoff is of special interest. A comprehensive description of cardiological effects following auto-HCST of CD133+ cells is given in this review, as based on follow-up of 223 patients from the RTC Registry. A need for further trials is suggested.

A short article Time- and sample-dependent differences in polyomavirus incidence following hematopoietic stem cell transplantation is dedicated to reactivation of polyomaviruses in immunocompromised patients, being a common consequence of the post-HSCT immune deficiency. E. g., the BK virus in urinary cells is generally associated with hemorrhagic cystitis after cytostatic treatment.

This issue also contains a collection of poster communications prepared by the workers from Russia, Belarus, Armenia, and Tajikistan and presented at the VIII Raisa Gorbacheva Memorial Meeting (September
18-22, 2015, Sochi, Russia). These abstracts provide a short view of the topics that are currently in scope of HSCT specialists working in the ex-USSR countries.

The CTT Journal also regrets upon the loss of Professor van Bekkum, a leader in hematopoietic stem cell research. An obituary written by G. Wagemaker is placed in this issue of the Journal.

Regular articles

Time- and sample-dependent differences in polyomavirus incidence following hematopoietic stem cell transplantation

Alexey B. Chukhlovin1, Yury A. Eismont2, Vladimir N. Vavilov1, Ludmilla S. Zubarovskaya1, Boris V. Afanasyev1

Short messages

Treatment of HIV-associated lymphomas: results of a multicenter retrospective study

Popova M.1, Shneyder T.2, Karaygin I.2, Zuyzgin I.2, 10, Ryabykina O.2, Ruzhinskaya O.2, Uspenskaya O.2, Medvedeva N.3, Klimovich A.3, Potapenko V.3, Kotova N.3, Zinina E.4, Popova N.4, Zhurba Y.4, Myasnikov A.5, Moshnina S.5, Evseev A.5, Kaplanov K.6, Ksenzova T.7, Karyagina E.8, Stolypina Zh.8, Dzola S.9, Levanov A.9, Mel’sitova K.1, Borzenkova E.1, Mikhaylova N.1, Zubarovskaya L.1 and Afanasyev B.1

Efficiency of hypoxic hypoxia during idiopathic thrombocytopenic purpura

Abduhalim R. Raimzhanov1, Irina A. Tsopova2, Mary O. Eralieva1, Bahtygul K. Aysarieva3

Graft-versus-host disease prophylaxis with post-transplantation cyclophosphamide

Olga V. Pirogova, Ivan S. Moiseev, Elena I. Darskaya, Sergej N. Bondarenko, Elena V. Babenko, Alexander L. Alyanskiy, Boris V. Afanasyev

Characteristics of early posttransplant phase in patients with multiple myeloma and different response to standard chemotherapy: single-center analysis of 130 cases

Galina D. Petrova, Kapitolina N. Melkova, Tatiana Z. Chernyavskaya, Nadezhda V. Gorbunova, Valentina N. Kostrykina, Vadim A. Doronin.

Evaluation of posttransplant relapse risk in patients with acute leukemia using the gene expression markers

Alena I. Shakirova1, Ildar M. Barkhatov1, Olga I. Shakirova2, Dmitry S. Romanyuk1, Alexei V. Evdokimov1,

Sergey N. Bondarenko1, Ludmila S. Zubarovskaya1, Boris V. Afanasyev1

Efficiency and safety of 5-azacitidine administration in acute myeloid leukemia and myelodisplastic syndrome after allogenic hematopoietic stem cell transplantation

Varvara N. Ovechkina, Sergey N. Bondarenko, Elena V. Morozova, Olga A. Slesarchuk, Anna G. Smirnova, Kirill A. Ekushov, Ludmila S. Zubarovskaya, Boris V. Afanasyev

Long-term observations of patients with Fanconi anemia following allogeneic hematopoietic stem cell transplantation: a two-center experience

Elena V. Skorobogatova1, Kirill I. Kirgizov1, Dmitry N. Balashov2, Natalia V. Sidorova1, Ekaterina A. Pristanskova1, Natalia V. Sidorova1, Veronika V. Konstantinova1, Oxana L. Blagonravova1, Pavel E. Trakhtman2, Yulia V. Skvortsova2, Michael A. Maschan2, Aleksey A. Maschan2

Evaluation of bone marrow stromal cells regarding their role in hematopoietic reconstitution

Nikolai Y. Tsvetkov, Ildar M. Barkhatov, Alain I. Shakirova, Dmitri S. Romaniuk, Olesya G. Smykova, Vera V. Teplyashina, Ludmila S. Zubarovskaya, Boris V. Afanasyev

Effective treatment of mixed viral infection in a patient after haploidentical stem cell transplantation

Larisa Vakhonina1, 2, Igor Vyatkin1, 2, Natalya Maysheva1, 2, Grigory Tsaur1, 2, 3, Oleg Medvedev1, 2, Leonid Saveliev1, 2, 3, Larisa Fechina1, 2

Genomic DNA breakpoints in MLL and translocation partner genes: correspondence to clinical parameters and treatment outcome in infants with acute leukemia

Grigory A. Tsaur1, Claus Meyer2, Anatoly M. Kustanovich3, Alexander M. Popov1, Tatiana O. Riger1, Elena W. Fleischman4, Olga I. Sokova4, Yulia V. Olshanskaya5, Elena А. Matveeva5, Olga V. Streneva1, Egor V. Shorikov1, Leonid I. Saveliev6, Rolf Marschalek2, Larisa G. Fechina1

Early diagnostics of acute kidney injury (AKI) associated with hematopoietic stem cell transplantation (HSCT)

Kirill A. Smirnov, Vladimir A. Dobronravov, Boris V. Afanasiev, Olga V. Galkina, Irina M. Zubina, Evdokia O. Bogdanova

Efficiency of antimicrobial surface treated central venous catheters in the prophylaxis of catheter-associated infections in children with oncohematological diseases

Yulia Simakina, Olga Ivanova, Elisa Kubieva, Elena V. Morozova, Ekaterina Goncharova, Ludmila S. Zubarovskaya, Boris V. Afanasyev

Instant lysis of therapeutic mesenchymal stem cells after intravenous infusion: role of complement system and in vitro prevention strategies

A. R. Muslimov, R. T. Mikhelashvili, E. V. Volchkov, K. V. Lepik, V. S. Sergeev, B. V. Afanasyev

10/10 compatibility in hematopoietic stem cell transplantations (HSCT) may improve outcomes as compared to 9/10: a single-center study

Natalia V. Sidorova1, Kirill I. Kirgizov1, Dmitry N. Balashov2, Pavel E. Trachtman2, Marina Y. Persiantseva2, Ekaterina A. Pristanskova1, Veronika V. Konstantinova1, Oxana L. Blagonravova1, Michael A. Maschan2, Elena V. Skorobogatova1, Alexey A. Maschan2

Pharmacokinetic comparison of cyclosporine A and tacrolimus for graft-versus-host disease prophylaxis

Moiseev Ivan S., Muslimov A. R., Pirogova Olga V., Darskaya Elena I., Slesarchuk Olga A., Bondarenko Sergej N., Afanasyev Boris V.

Impact of cytogenetics on outcome of acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation

Tatiana L. Gindina, Nikolay N. Mamaev, Sergey N. Bondarenko, Alexander L. Alyanskiy , Olga A. Slesarchuk, Ivan S. Moiseev, Olga V. Pirogova, Svetlana V. Razumova, Lyudmila S. Zubarovskaya, Boris V. Afanasyev

17q21→17qter jumping translocations in a 13-year-old girl with RUNX1–RUNX1T1- positive acute myeloid leukemia

Tatiana L. Gindina, Nikolay N. Mamaev, Elena S. Nikolaeva, Olga S. Uspenskaya, Irina A. Petrova, Marya Yu. Averyanova, Sergey N. Bondarenko, Boris V.Afanasyev

Results of high-dose chemotherapy with autologous hematopoietic stem cell transplantation in treatment of pediatric brain tumors

Asmik G. Gevorgian1, Elena V. Morozova1, Ilya V.Kazantsev1, Tatiana V. Iukhta1, Svetlana A. Safonova1, Yury A. Punanov1, Ludmila S. Zubarovskaya1, Olga G. Zheludkova2, Boris V. Afanasyev1

Prevalence of hematological malignancies in Armenia

Smbat S. Daghbashyan, Nata A. Melkikyan, Lussine.S. Sahakyan, M.V.Saharyan, R.Yolyan

Epidemiology and risk factors for bacterial infections (BI) in children and adolescents after allogeneic hematopoietic stem cell transplantation (allo-HSCT)

Maria Yu. Averianova1, Vladimir N. Vavilov1, Natalia V. Stancheva1, Svetlana V. Razumova1, Anastasia S. Borovkova1, Olesya V. Paina1, Polina V. Kozhokar1, Kirill A. Ekushov1, Andrey V. Kozlov1, Yulia G. Fedukova1, Inna V. Markova1, Yana V. Gudozhnikova1, Anna A. Spiridonova1, Nadezhda А. Schaliapina2, Svetlana A. Riachovskych2, Anna V. Lubimova2, Ludmila S. Zubarovskaya1, Boris V. Afanasyev1

Allogeneic stem cell transplantation in myelofibrosis patients with intermediate-2 and high DIPSSplus risk

Maria V. Barabanshikova, Elena V. Morozova, Vadim V. Baikov, Ludmila S. Zubarovskaya, Boris V. Afanasyev

Low-dose cytarabine and cladribine for treatment of relapsed or refractory acute myeloid leukemia: clinical experience

Sergej V. Gritsaev, Ivan I. Kostroma, Anastasia A. Kuzjaeva, Irina M. Zapreeva, Elena V. Litvinskaya, Lubov V. Steljmashenko, S. A. Tiranova, Irina S. Martinkevitch, Nadezhda A. Potichonova, Kudrat M. Abdulkadyrov.

Hematopoietic stem cell transplantation in patients with neurometabolic diseases: a single center experience

Kirill I. Kirgizov1, 2, Ekaterina A. Pristanskova1, Yulia V. Skvortsova2, Natalia L. Pechatnikova1, Marina Y. Persiantseva2, Natalia V. Sidorova1, Dmitry N. Balashov2, Veronika V. Konstantinova1, Oxana L. Blagonravova1, Svetlana M. Mikhailova1, Elena V. Skorobogatova1, Aleksey A. Maschan2

Influence of co-transplanted mesenchymal stem cell upon immunological recovery after allogeneic hematopoietic cell transplantation in children

Yuliya E. Mareika, Tatiana V. Shman, Yanina I. Isaikina, Nina V. Minakovskaya, Natalia P. Kirsanava, Olga V. Aleynikova

Mesenchymal stem cells: multilayer polyelectrolyte microcapsules uptake, toxicity and influence upon functional properties

K. V. Lepik1, V. S. Sergeev1, A. R. Muslimov1, D. S. Romanyuk1, R. T. Mikhelashvili1, I. S. Moiseev1, E. V. Popova2,I. L. Radchenko2, A. D. Vilesov1, G. B. Sukhorukov2, 3, B. V. Afanasyev1

Chimerism analysis after allogeneic hematopoietic stem cell transplantation as a prognostic factor of relapse in hematopoietic malignancies in children

Victoria A. Lavrinenko, Yulia E. Mareiko, Tatsiana V. Savitskaya, Mikhail V. Belevtsev, Olga V. Aleynikova

Effectiveness of high-dose chemotherapy with autologous stem cell transplantation (ASCT) in patients with relapsed and refractory course of Hodgkin’s lymphoma

Elena V. Kondakova, Natalya B. Mikhailova, Evgenia S. Borsenkova, Olga B. Kalashnikova, Nadezhda V. Medvedeva, V. V. Ryabchikova, Boris V. Afanasyev

Aberrant methylation of promoter regions of sox7, p15ink4b and WNT pathway antago- nist genes in patients with myelodysplas- tic syndrome

Ivan I. Kostroma, Sergey V. Gritsaev, Zh. Yu. Sidorova, S. A. Tiranova, S. P. Svitina, Yulia S. Drizhun, Irina S. Martinkevitch, Kudrat M. Abdulkadyrov, Sergej I. Kapustin, Alexander V. Chechetkin

Treatment of refractory chronic graft-versus-host disease with interleukin-2

Ivan S. Moiseev, E.A. Burmina, Olga V. Pirogova, Olga A. Slesarchuk, Sergej N. Bondarenko, Boris V. Afanasyev

Obituary